Your Digest for Thursday, Nov 30, 2023 02:59 PM


Mean pulmonary venous pressure (= LAP = [[2023-NOV-GM#Pulmonary capillary wedge position and pressure| Wedge Pressure]]) = 5mmHg.


pharmaceuticalTrials.png


Muscarinic receptors

Muscarinic receptors are G-coupled protein receptors involved in the parasympathetic nervous system.
The only exception to this rule are the receptors is the sweat glands, which possess muscarinic receptors but are part of the sympathetic nervous system. Source
Mnemonic: Musca-para-Gee



L-dopa -> Dopamine -> Norad -> adrenaline -> ?waste products


| Phentolamine | Non selective alpha adrenergic blocker; | Used in catecholamine induced hypertension (phaeochromocytoma, tyramine ingestion in patient on MAOI |


Multiple Endocrine neoplasia syndromes

Pulmonary capillary wedge position and pressure (PCWP)

#2023GM-NOV/Q02
pulmonaryCapillaryWedgePressure.pngPressure transduced catheter is introduced into the femoral or jugular vein.

Basic Science

Source

Clinical context

Phaeochromocytoma

Basic Science

Clinical context

Paraganglioma Phaeochromocytoma
head and neck Adrenal medulla
Noradrenaline Adrenaline and noradrenaline
More associated with genetic syndromes Can be associated with MEN2
Associated with succinate dehydrogenase gene mutations
Higher malignancy risk